The Probe and Surface Laboratory at Novascan Technologies offers AFM probes with defined chemistries useful in a number of AFM applications including chemical force microscopy (CFM). These probes have proven a powerful tool for characterizing surfaces, studying molecular forces and chemical sensing.

Chemically modified probes are comprised primarily of either thiol-based or silane-based self assembled monolayers (SAMs) covalently attached to the surface of commercially available AFM probes. Thiol modified probes, available with CH₃, COOH, OH and succinimide end groups, are attached via chemical absorption to a freshly applied layer of gold. Alternatively, silane monolayers, including APTES, are tethered to oxide layers on the surface of AFM probes. Further modifications can yield a variety of surface chemistries including NH₃, maleimide, biotin, streptavidin, neutravidin, antibodies, PEG linkers and a number of other molecules.

Many of these modifications can also be performed on probes that have previously been modified with the attachment of SiO₂, borosilicate glass or polystyrene particles. As is always the case at Novascan, we welcome the opportunity to discuss custom modifications including custom particle attachment or chemical modifications.

• Inter-molecular Force Measurement
• Chemical Sensing and Detection
• Hydrophilic/Hydrophobic Interaction
• Attractive/Repulsive Regimes
• Adhesion Forces
• Unbinding Forces
• Surface Mapping

CT.AU.OH - Au coated probe with an OH surface chemistry
CT.AU.COOH - Au coated probe with a COOH surface chemistry
CT.AU.CH3 - Au coated probe with a CH₃ surface chemistry
CT.AU.NH3 - Au coated probe with an NH₃ surface chemistry
CT.AU.SUC - Au coated probe with a succinimide surface chemistry
CT.AP - APTES coated AFM probe
CT.AU.SA - Au coated probe with a streptavidin surface chemistry
CT.AU.NA - Au coated probe with a neutravidin surface chemistry
CT.BIO - AFM probe with a biotin surface chemistry

CT.PEG.BIO - Biotin terminated flexible PEG linker
CT.PEG.NH3 - NH₃ terminated flexible PEG linker
CT.PEG.MAL - Maleimide terminated PEG linker
CT.PEG.COOH - COOH terminated flexible PEG linker
CT.PEG.AB - Flexible PEG linker with covalently attached antibody

PT.GS - Glass Particle
PT.GS.AP - Glass Particle - Amino Silanized (APTES)
PT.GS.AU - Glass Particle - Gold coated
PT.GS.CONDUC - Glass Particle - Gold Coated for Conductivity
PT.GS.AU.NH3 - Glass Particle - Gold coated with NH₃ surface
PT.GS.AU.COOH - Glass Particle - Gold coated with COOH surface
PT.GS.AU.SUC - Glass Particle - Gold coated with Succinimide surface
PT.GS.AU.CH3 - Glass Particle - Gold coated with CH₃ surface
PT.GS.PEG.BIO - Glass Particle with Biotin terminated flexible PEG linker
PT.GS.PEG.NH3 - Glass Particle with NH₃ terminated flexible PEG linker
PT.GS.PEG.MAL - Glass Particle with Maleimide terminated flexible PEG linker
PT.GS.PEG.COOH - Glass Particle with COOH terminated flexible PEG linker
PT.GS.AU.SA - Particle Probe, Au with a streptavidin surface chemistry
PT.GS.AU.NA - Particle Probe, Au with a neutravidin surface chemistry

PT.PS - Polystyrene Particle
PT.PS.NH3 - Polystyrene Particle with NH₃ surface
PT.PS.COOH - Polystyrene Particle with COOH surface
PT.PS.SA - Polystyrene Particle with Streptavidin surface
PT.PS.BIO - Polystyrene Particle with Biotin surface

PT.PE - Polyethylene Particle - please enquire for sizes. Note: These particles are quite soft.

PT.CUST - Custom Particle Attachment
PT.TUNG - Tungsten Particle